Diethyl Thiophosphate Chloride (cas No.2524-04-1)

General Description
A colorless to light amber liquid with a disagreeable odor. Density 1.196 g / cm3. Boiling point 120°F.Flash point below 100°F. Insoluble in water but soluble in most organic solvents. May be highly toxic and irritating to the eyes and lungs. Used as an intermediate for pesticides, as an oil and gasoline additive, and as a flame retardant.
 
Air & Water Reactions
Highly flammable. Insoluble in water but soluble in most organic solvents. Contact with moisture in the air produces highly corrosive and toxic fumes containing hydrogen chloride. Decomposes in water producing acidic products.

Reactivity Profile
Diethyl chlorothiophosphate is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
 
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Diethyl Thiophosphate Chloride (cas No.2524-04-1)
P-Toluenesulfonamide(casNo.70-55-3)

Chemical Properties
It is white flaky crystal. It is soluble in ethanol but insoluble in water and ether.  

Uses
1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener.
 2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes.
 3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2 ~ 0.3 g / L.
 4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin.

Production methods
It is obtained by the reaction between toluenesulfonyl chloride and ammonia.
 First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85 ~ 90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products. 

Chemical Properties
white crystalline powder
 
Usage
4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs. 
 
Usage
Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc. 

P-Toluenesulfonamide(casNo.70-55-3)